Formulation and development of microemulsion and smedds akshay r. The purposes of the present study were to develop a selfmicroemulsifying drug delivery system smedds containing bortezomib, a proteasome inhibitor. Smedds were prepared by admixing method using peceol and captex 200 as oil phases. Later they obtained liquid smedds were converted in to free flowing powder using adsorbent like aerosil 200. Formulation of smedds the following should be considered in the formulation of smedds. Pharmaceutics free fulltext formulation development. Liquid formulation can easily be converted into free flowing powder form by. Ease of administration and painless approach made oral route the most preferred. In conclusion, the present smedds improved the oral bioavailability of ajs dramatically and was a promising strategy for the drugs oral delivery. Formulation, invitro evaluation and stability studies article pdf available march 2017 with 212 reads how we measure reads. Albendazole is an anthelmintic agent with poor solubility and absorption.
The pharmacokinetic study was performed in rats, and the drug concentration in plasma samples was assayed using the highperformance liquid chromatographyelectrospray tandem mass. The dissolution characteristics of solid intermediates of smedds filled into hard gelatin capsules was investigated and compared with liquid formulation and commercial formulation to ascertain the impact on self. Selfmicroemulsifying drug delivery system wikipedia. Failure to attain intended therapeutic effect of the poor water soluble drugs by this route led to development of novel drug delivery systems which will fulfill. By using the formulation, the ajs bioavailability was increased by 35.
In order to select proper components for the preparation of smedds. The optimized formulation was studied for in vitro study and was found that the formulation containing labrafac cc 28. So, preformulation solubility and phase diagram studies are required in order to obtain an optimal formulation design. A smedds oil formulation representing type iii a lipid class was converted into ssmedds using solid carrier adsorption method and compressed into tablets containing theophylline. Solid selfmicroemulsifying formulation for candesartan. Selfmicroemulsifying drug delivery system smedds taylor. Improved dissolution and oral bioavailability of valsartan.
Smedds were characterized with respect to mean globule size and in vitro drug release pro. C and evidence of any phase separation, flocculation or precipitation is observed. Enhancement of solubility and therapeutic potential of poorly soluble. Declaration i declare that the thesis entitled formulation and evaluation of solid self microemulsifying drug delivery system submitted by me for the degree of doctor of philosophy is the record of research work carried out by me during the period march 2011 to february. Smedds formulations of varying proportions of peceol, cremophor rh 40 and.
Labrafil m2125 as surfactant and transcutol and plurololeique as cosurfactants. Son hy, chae br, choi jy, shin dj, goo yt, lee es, et al. The very essence of smedds is selfemulsification, which is primarily assessed visually. Research article formulation and evaluation of self micro emulsifying system of candesartan cilexetil jill 1,b.
The effect of oil loading factor on compressibility, disintegration and dissolution kinetics of theophylline from various tablet formulation was investigated. Formulation and characterisation of selfmicroemulsifying. This article is from iranian journal of pharmaceutical research. Effect of selfmicroemulsifying lipid formulations on the. A selfmicroemulsifying drug delivery system smedds is a drug delivery system that uses a microemulsion achieved by chemical rather than mechanical means. The optimized liquid smedds formulation c7iib was converted into free flowing powder by adsorption of liquid onto solid carriers that provided a high surface area with good disintegration characteristic the soild carriers used includes aerosil 200 pharma a1. Optimisation and in vivo evaluation of pectin based drug delivery system containing curcumin for colon. In this method, adding the oil, surfactant mixture to some of the aqueous phase in a. Composition of smedds formulation typically, a smedds formulation comprises of drug, oil, surfactant and cosurfactant drug lipophilicity and dose of the drug are the main criteria to be considered before development of smedds formulation.
Patel2 1 departments ofpharmaceutics, malibacollege pharmacy, veer narmad southgujaratuniversity, surat 394350, india, 2 department of pharmaceutics, college of pharmacy, sumandeep vidyapeeth university, vadodara 391760, india. However, it has a low bioavailability after being administered orally on account of its low solubility in water. Contents of the powerpoint on self emulsifying drug delivery systems sedds include. Selfemulsifying drug delivery systems sedds in pharmaceutical development beatriz zanchetta1,2, marco vinicius chaud3 and maria helena andrade santana1, 1department of engineering of materials and bioprocesses, school of chemical engineering, university of campinas, sp, brazil. The purpose of this study was to prepare a dutasterideloaded solidsupersaturatable selfmicroemulsifying drug delivery system smedds using hydrophilic additives with high oral bioavailability, and to determine if there was a correlation between the in vitro dissolution data and the in vivo pharmacokinetic parameters of this. Ajs smedds formulation was optimized in terms of drug solubility in the excipients, droplet size, stability, and drug precipitation using a pseudoternary diagram. Ideally, drug should have low dose, log p 2 and should not possess extensive first pass metabolism. The relative bioavailability of the smedds formulation to.
Formulation and evaluation of a selfmicroemulsifying drug. Development of a selfmicroemulsifying drug delivery system of. Design and evaluation of telmisartan smedds for enhancing. T1 inclusion of digestible surfactants in solid smedds formulation removes lag time and influences the formation of structured particles during digestion. The solubility of the drug was evaluated in 15 pharmaceutical excipients. A selfmicroemulsifying drug delivery system smedds for. Furosemide is class iv molecule according to bcs biopharmaceutical classification system, having low solubility and low permeability. Results of diffusion rate and oral bioavailability of flurbiprofen smedds were compared with those of pure drug solution and of marketed formulation. That is, by an intrinsic property of the drug formulation, rather than by special mixing and handling. This solid smedds formulation could be an outstanding. It employs the familiar ouzo effect displayed by anethole in many aniseflavored liquors.
Thus, we suggested that phospholipid complex formation and smedds formulation using the experimental design method might be a promising approach to enhance the dissolution of poorly soluble drugs. In order to improve the dissolution rate, silymarin was formulated in the form of a selfmicroemulsifying drug delivery system smedds. Formulation, in vitro evaluation, and stability studies article pdf available in aaps pharmscitech 102. For the love of physics walter lewin may 16, 2011 duration. Selfmicro emulsifying drug delivery system smedds is class of emulsion that has received particular attention as a means of enhancing oral bioavailability of poorly water soluble drugs. Selfmicroemulsifying drug delivery system smedds for improved. Patel2 1 departments ofpharmaceutics, malibacollege pharmacy, veer narmad southgujaratuniversity, surat 394350, india, 2 department of pharmaceutics, college of pharmacy, sumandeep vidyapeeth. It was also seen that changes in the dissolution medium buffer ph 1. Solubility study of lurasidone hydrochloride lh was carried out in various surfactants, co surfactants and oils. Pdf a selfmicroemulsifying drug delivery system smedds has been. Based on the solubility study and the pseudoternary phase diagram of microemulsion, the amounts of oil, surfactant and cosurfactant were chosen as the independent variables. The optimum formulation of smedds containing silymarin was. Formulation design of selfmicroemulsifying drug delivery.
Pdf formulation and evaluation of self microemulsifying. Aim of the present investigation was to develop the self microemulsifying drug delivery system smedds of furosemide. Selfmicroemulsifying drug delivery system smedds challenges and road ahead. Olmesartan medoxomil olm is an angiotensin ii receptor blocker arb antihypertensive agent administered orally that has absolute bioavailability of only 26% due to the poor aqueous solubility 7. Selfmicro emulsifying drug delivery system smedds is class of emulsion that has received particular attention as a means of.
Selfmicroemulsifying drug delivery system of phillygenin mdpi. The two phases of the emulsion tend to separate with time to reduce the interfacial area and thus the free energy of the system. The combination system of pc and smedds had a synergistic effect on improving the oral absorption of ba. Formulation types are based on the lipid formulation classification system lfcs. Pharmaceutical nanotechnology development of smedds. Capsugel scientists have developed many selfemulsifying drugdelivery systems sedds and selfmicro emulsifying drugdelivery systems smedds for the oral administration of drugs with poor aqueous solubility. Smedds is dependent upon the particular physicochemical compatibility of the drugsystem 11. The aim of the present investigation was to develop a selfmicroemulsifying drug delivery system smedds to enhance the oral absorption of olm. Selfmicro emulsifying drug delivery system smedds is the one of the method for improvement of oral bioavailability. The objective of the study was to enhance solubility of lurasidone hcl, an atypical antipsychotic drug, by formulating selfmicro emulsifying drug delivery system smedds and its characterization. Preparation and characterization of selfmicroemulsifying. Optimization of selfmicroemulsifying drug delivery system.
Inclusion of digestible surfactants in solid smedds. Evaluation of carbamazepine cbz supersaturatable self. Formulation of selfmicroemulsifying drug delivery system. The supersaturatable selfmicroemulsifying drug delivery system ssmedds represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of surfactant and a watersoluble polymer precipitation inhibitor or supersaturated promoter to prevent precipitation of the drug by generating and maintaining a supersaturated. Design and development of solid self micro emulsifying. We developed a chewable tablet 200 mg drug equivalent, containing a selfmicroemulsifying drug delivery system smedds, with oral disintegrating properties. The smedds formulation optimized via mixture design consisted of 49. Poor oral bioavailability is pronounced with the majority of recent active ingredients because of dissolution rate limited absorption.
Formulation and biopharmaceutical evaluation of silymarin. The free energy of a conventional emulsion formulation is a direct function of the energy required to create a new surface between the oil and water phases. Silymarin has been used to treat hepatobiliary diseases. The composition of the smedds formulation was optimized by using doptimal mixture design. After mixing the smedds components, pol was added as 10% ww of. Combinations of oils, surfactants and cosurfactants were screened by drawing pseudoternary phase diagrams. Preparation and pharmacokinetics evaluation of oral self. The selfmicroemulsification properties, droplet size, and zeta potential of these formulations were studied upon dilution with water. The optimized liquid smedds formulation was converted into free flowing powder by adsorbing onto a solid carrier for encapsulation. Abstract the supersaturatable selfmicroemulsifying drug delivery system ssmedds represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of surfactant and a watersoluble polymer precipitation inhibitor or supersaturated. The emulsion was developed using sesame and soybean oils along with surfactantcosurfactants, and the tablets were prepared by wet.
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